发明名称 (5,6-dichloro-3-oxo-9A-propyl-2,3,9,9A-tetrahydrofluoren-7-yl)alkanoic acids and alkanimidamides
摘要 The invention relates to novel [(5,6-dichloro-3-oxo-9a-propyl-2,3,9,9a-tetrahydrofluoren-7-yl)]alkanoic acids and alkanimidamides, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections, various brain concussions and elevated intracranial pressure.
申请公布号 US4731472(A) 申请公布日期 1988.03.15
申请号 US19860835598 申请日期 1986.03.03
申请人 MERCK & CO., INC. 发明人 PIETRUSZKIEWICZ, ADOLPH M.;WOLTERSDORF, JR., OTTO W.;CRAGOE, JR., EDWARD J.
分类号 C07C45/67;C07C45/68;C07C49/747;C07C49/755;C07C59/88;(IPC1-7):C07C59/86 主分类号 C07C45/67
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