| 发明名称 |
Human osteoclast-derived cathepsin |
| 摘要 |
Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
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| 申请公布号 |
US6475766(B1) |
申请公布日期 |
2002.11.05 |
| 申请号 |
US19950553125 |
申请日期 |
1995.11.07 |
| 申请人 |
HUMAN GENOME SCIENCES, INC.;SMITHKLINE BEECHAM CORPORATION |
发明人 |
HASTINGS GREGG A.;ADAMS MARK D.;FRASER CLAIRE M.;LEE NORMAN H.;KIRKNESS EWEN F.;BLAKE JUDITH A.;FITZGERALD LISA M.;DRAKE FRED H.;GOWAN MAXINE |
| 分类号 |
G01N33/53;A61K31/70;A61K38/00;A61K38/46;A61K38/48;A61K39/395;A61K48/00;A61P19/08;A61P19/10;A61P35/00;A61P43/00;C07H21/00;C07H21/02;C07H21/04;C07K14/47;C07K16/40;C12N1/19;C12N1/21;C12N5/10;C12N9/48;C12N9/50;C12N9/64;C12N15/09;C12N15/11;C12N15/57;C12N15/66;C12P19/34;C12P21/00;C12P21/02;C12P21/08;C12Q1/37;G01N33/535;(IPC1-7):C12N9/64 |
主分类号 |
G01N33/53 |
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