发明名称 |
METHOD FOR MAINTENANCE AND PROPAGATION OF GERMLINE STEM CELLS USING MEMBERS OF THE TFG-B FAMILY OF GROWTH FACTORS |
摘要 |
The TGF-beta family of growth factors, particularly the bone morphogenetic protein (BMP)-2/4 homolog decapentaplegic (dpp), are specifically required to maintain germline stem cells and promote their division. Overexpression of dpp blocks germline stem cell differentiation. Mutations in dpp or its receptor saxophone accelerate stem cell loss and retard stem cell division. dpp signaling is directly received by germline stem cells, and thus dpp signaling helps define a niche that controls germline stem cell proliferation.
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申请公布号 |
US2002168694(A1) |
申请公布日期 |
2002.11.14 |
申请号 |
US19990358937 |
申请日期 |
1999.07.23 |
申请人 |
SPRADLING ALLAN C.;XIE TING |
发明人 |
SPRADLING ALLAN C.;XIE TING |
分类号 |
A01K67/033;C12N5/02;C12N5/07;C12N5/10;C12N15/09;(IPC1-7):G01N33/567;C12P21/04;A61K48/00;C12N15/87 |
主分类号 |
A01K67/033 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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