| 摘要 |
NEW MATERIAL:The compound of formula I (R<1> is H, lower alkyl, halogen, nitro, lower, alkoxy, etc. R<2> is H or lower alkyl; R<3> is H, group of formula II or formula III; R<4> is H, lower alkyl, lower alkoxy, lower alkanoyloxy, etc.; R<5> is group of formula IV or -B-X; R<8> and R<9> are H, lower alkyl, 3-6C cycloalkyl, etc.; R<8> and R<9> may together form group of formula V, etc.; R<10> is H, lower alkyl, etc.; X is halogen, methanesulfonyloxy, etc.; Z is H, lower, alkyl, lower alkoxy, etc.; A and B are 1-6C lower alkylene; l is 2 or 3; m is 0 or 1; n is 0 or 1) and its salt. USE:The compound has platelet coagulation inhibiting and calcium antagonistic activities, etc., and is useful as a remedy for circulatory diseases. PREPARATION:The compound of formula I can be produced e.g. by reacting the compound of formula VI with a reducing reagent and reacting the reaction product with the compound of formula VII (Y is halogen, etc.). |
