CYCLODEXTRINCLATHRATES OF CARBACYCLINE DERIVATIVES AND THEIR USE AS MEDICINAL DRUGS

摘要

Pharmaceutical preparations contg. a cyclodextrin clathrate of a carbacyelin of formula (I) as the active component, together with pharmaceutically innocuoeus carvise substances and adjuvants are new. R1 = H or opt. branched 1-10C alkyl; A = -CH2CH2-, trans-CH0CH-, or -C=C-; W = tec or fucntionally modified -CHOH-or -C(CH3)(OH)-group in which the OH groups may have alpha or beta D = (II) unbranched satd., 1-5C alkylene, or opt. branched unsatd. 2-5C alkylene opt. substd. by F-atoms; m = 1,2 or 3; E = direct bond, -c=c-, or -CR4=CR5- (R4 = H or 1-5C alkyl; R5 = H, halogen or 1-5C alkyl); R2 = 1-10C alkyl, 3-10C cycloalkyl, opt. substd. 6-10C aryl or a hetrocyclic group; R3 = fee or functionally modified OH; n = 1,2,3,4 or 5; x = CH2 or 0.