| 摘要 |
NEW MATERIAL:A quinoline derivative expressed by formula I (R<1> is H; R<2> is lower alkyl which may have a substituent group or R<1> and R<2> together with the adjacent N atom may form a ring which may contain other N, O or S or may have a substituent group; R<3> is nitro, amino or acylamino). EXAMPLE:8-Nitro-5-[4-(p-nitrobenzoyl)piperazino]quinoline. USE:With anti-inflammatory, cardiotonic action, etc., and useful as a medicine. PREPARATION:For example, a compound expressed by formula II is reacted with a compound expressed by formula III in an amount of preferably 2-8mol based on 1mol compound expressed by formula II at room temperature - refluxing temperature of a solvent used to afford the aimed compound expressed by formula Ia in the compound expressed by formula I. |
