A PHARMACEUTICAL COMPOSITION USEFUL AS A LEISHMANICIDAL AGENT

摘要

This invention relates to the leishmanicidal activity of night jasmine leaf extract, wherein the said method comprises the steps of, preparing the methanolic extract of night jasmine leaf, chromatographic purification of said extract to obtain bioactive fraction containing calceolarioside A, isolation and characterization of calceolarioside A, leishmanicidal activity of calceolarioside A against axenic promastigote culture of Leishmania donovani, treatment of L. donovani infected chronic golden hamster with bioactive fraction for a period of 21 days for detection of leishmanicidal activity in vivo, administering of PE in normal hamster to obtain non-toxic nature, combination therapy of bioactive fraction + SAG against said model for synergistic potentiation of antileishmanial activity and complete clearance of parasitemia from liver and spleen as reflected by LDU wherein comprising a potential medicament against kala-azar.