CRYSTALLINE IRINOTECAN HYDROCHLORIDE POLYMORPHOUS FORM, METHOD FOR ITS PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF

摘要

FIELD: organic chemistry of natural compounds, medicine, pharmacy. ^ SUBSTANCE: invention elates to a novel polymorphous form (C) of crystalline irinotecan hydrochloride of the formula: This form is characterized by X-ray diffraction picture on a powder with values of angle 2theta about 9.15; about 10.00; about 11.80; about 12.20; about 13.00 and about 13.40 and showing infrared spectrum comprising peaks at 1757, 1712 and 1667 cm-1. The novel polymorphous form (C) is used in treatment of cancer diseases but as distinct from the known polymorphous form (b) it possesses significantly greater solubility in water that allows its using both oral and parenteral administration. ^ EFFECT: improved and valuable properties of drug. ^ 19 cl, 2 dwg, 4 tbl, 6 ex