MENTHYL 2,2-DIMETHYLCYCLOPROPANECARBOXYLATE AND RESOLUTION OF THE SAME

摘要

An ester obtained from 2,2-dimethylcyclopropanecarboxylic acid and optically active menthol, represented by the formula, is effectively resolved into diastereomers, which upon hydrolysis give optically active 2,2-dimethylcyclopropanecarboxylic acid. Unnecessary diastereomeric ester, remained after resolution, can be epimerized selectively on the acid moiety. Combination of the resolution and the epimerization provides an efficient method for production of optically active 2,2-dimethylcyclopropanecarboxylic acid.