| 摘要 |
<p>This invention provides a method for reducing the intraocular pressure in mammals which comprises administering an effective amount of a compound selected from the group consisting of compounds represented by the general formula: <CHEM> where R2, R3 and R4 are each selected from the group consisting of H and OA; A is H or is selected from the group consisting of hydrocarbyl radicals, e.g. lower alkyl radicals, i.e. methyl, ethyl, propyl etc., or - @-R5, wherein R5 is selected from the group consisting of hydrocarbyl radicals, e.g. alkyl and aromatic residues; n is 2 or 3; and R1 is selected from the group consisting phenyl and substituted phenyl, e.g. phenyl substituted with hydroxy, nitro, azido, sulfate, sulfonamido, halogen, hydrocarbyl and hetero atom-substituted hydrocarbyl radicals, wherein said heteroatoms are selected from the group consisting of halogen, nitrogen, oxygen, sulfur and phosphorus and said hydrocarbyl radicals comprise from 1 to 12 carbon atoms, with the proviso that at least one of R2, R3 and R4 is H, that at least one of R2, R3 and R is not H and that R2 and R4 are not both OA; and pharmaceutically-acceptable salts thereof, in an ophthalmic carrier. Preferably, R is phenyl or 3 or 4 hydroxyphenyl.</p> |
