| 摘要 |
This invention relates to compounds of general formula (I) <IMAGE> and their physiologically acceptable salts and their solvates, where X represents a C1-7 alkylene, C2-7 alkenylene or C2-7 alkynylene chain, Y represents a bond or a C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene chain with the condition that the total sum of carbon atoms in chains X and Y is 5, 6 or 7, R1 and R2 each independently represent a hydrogen atom or a methyl group, Q represents HCO-, CH3CO-, NH2CO-, (CH3)2NSO2- or CH3SO2- and Ar represents a phenyl group substituted with a group selected from amino, dimethylamino, nitro, morpholino, (CH2)qNHCOR6 (where R6 is C1-4 alkyl and q is 0 or 1), -NHSO2R7 (where R7 is C1-4 alkyl), -COR8 (where R8 is C1- 4 alkoxy, or -NR3R4 where R3 and R4 are both C1-4 alkyl or -NR3R4 forms a piperidine ring), -CH2CONR3R4 (where R3 and R4 are both C1-4 alkyl), -SR9 (where R9 is C1-4 alkyl) or -(CH2)rR10 (where r is 3 and R10 is C1-4 alkoxy) or Ar is 3,5-dihydroxyphenyl or 3-methoxy-4- hydroxyphenyl or when X and/or Y represent an alkenylene or alkynylene group, Ar may further represent a phenyl group optionally substituted with a fluorine atom; and their physiologically acceptable salts and solvates. The compounds have a selective stimulating effect on the β 2-adrenoreceptors and can be used among other things in the treatment of diseases associated with reversible obstruction of the airways such as asthma and chronic bronchitis.
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