| 摘要 |
PURPOSE:To economically and advantageously obtain the titled compound useful as a medicine, etc., in good yield, by reacting a substituted benzyl chloride with CO and an alkaline earth metal base in the presence of a cobalt carbonyl compound catalyst using water and a solvent sparingly soluble in the water as a solvent. CONSTITUTION:A substituted benzyl chloride, e.g. p-fluorobenzyl chloride, etc., is reacted with carbon monoxide and an alkaline earth metal base, particularly preferably calcium hydroxide in the presence of a cobalt carbonyl compound, particularly preferably dicobalt octacarbonyl to give a substituted phenylpyruvic acid, e.g. p-fluorophenylpyruvic acid, etc. In the process, water and a solvent sparingly soluble in the water, preferably a ketone, particularly methyl isobutyl ketone or acetophenone are used as a solvent. EFFECT:The catalyst is readily separated and reuse thereof can be carried out. |
