| 摘要 |
NEW MATERIAL:The compound of formula I [R<1> and R<2> are H, halogen, NO2, alkyl, amino, OH, alkoxycarbonyl or together form (CH2)m (m is 3-5) or O-(CH2)n-O (n is 1-3); R<3> is H or alkyl; R<4> and R<5> are H, halogen, alkyl or OH; A is alkylene] or its acid addition salt. EXAMPLE:2-{3-[4-(4-Fluorophenyl)-1-piperazinyl]-propyl}-6, 7, 8, 9-tetrahydro-2H- naphtho[2,3-b][1,4]-oxazin-3(4H)-one. USE:A drug having strong hypotensive and vasodilating action, etc. PREPARATION:The compound of formula I can be produced e.g. by reacting the compound of formula II (X is eliminable group) with the compound of formula III in the presence of a proper acid acceptor 50-150 deg.C. |
