DEVELOPMENT SYSTEM OF FILAMENTOUS FUNGI

摘要

Novel expression constructs for secretion of protein products in filamentous fungal hosts are provided. The hosts are transformed with the constructs, normally under conditions for multiple integration of the constructs into the host genome, where the desired protein products are expressed and secreted from the host to provide for enhanced yields of the product, substantially free of host proteins. Efficient filamentous fungal promoters are employed which may be from the same or different gene from the signal leader sequence.