| 发明名称 |
ARALKYLAMINOETHANOL HETEROCYCLIC COMPOUNDS |
| 摘要 |
Aralkylaminoethanol heterocyclic cpds. of formulae (I)-(VIII) and their tautomers, individual enantiomers and pharmaceutically acceptable salts are new. R1 is H or OH. Z is O or NH. R is CH(OH)CH2NHR3 R3 is a gp. of formula (IX). R4 and R5 are H or 1-3C alkyl. Y is (CH2)m when m is 1-4 or CH2O. R6 is H, OH, OCH3, halogen, methylenedioxy or 1-3C alkyl, n is 1 or 2. They have beta-adrenergic blocking, intra-ocular pressure reducing, antihypertensive and bronchodilating activity. |
| 申请公布号 |
DE3278014(D1) |
申请公布日期 |
1988.02.25 |
| 申请号 |
DE19823278014 |
申请日期 |
1982.10.01 |
| 申请人 |
MERCK & CO. INC.;MERCK SHARP & DOHME (I.A.) CORP. |
发明人 |
ATKINSON, JOSEPH G.;BALDWIN, JOHN J.;MCCLURE, DAVID E. |
| 分类号 |
C07D213/61;C07D213/64;C07D213/73;C07D213/89;C07D263/58;C07D265/36;C07D405/04;C07D471/04;(IPC1-7):C07D213/30;C07D213/38;A61K31/44;A61K31/42;A61K31/535 |
主分类号 |
C07D213/61 |
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