RESOLUTION OF THE RACEMATES OF PRIMARY AND SECONDARY AMINES BY ENZYME-CATALYZED ACYLATION

摘要

A process for producing optically active primary and secondary amines from t he corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon ato m; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produce d; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.