Bacterial cell extract, process for preparing same, antitumor preparation containing same, and adjuvant preparation containing same

摘要

Cells of a microorganism, such as Mycobacterium tuberculosis, belonging to the genus Mycobacterium are disrupted in distilled water or a suitable buffer solution, and then centrifuged or filtrated to remove the cell wall residue. To the aqueous cell-free extract is added a polyvalent metal salt or an antibiotic, such as streptomycin sulfate, which acts as a flocculant to form a precipitate. The precipitate consists essentially of sugar, protein, lipid, and nucleic acid. Owing to its high antitumor and adjuvant activities as well as its slight side effects, it can be used as antitumor and adjuvant preparations.