摘要 |
PURPOSE:To produce the title compound which is used as a synthetic intermediate of medicines in high yield, by the reaction of sodium p-chlorophenolate with m-dichlorobenzene in the presence of a copper catalyst and adding a specific compound which is liquid under the reaction conditions. CONSTITUTION:The objective compound is obtained by reaction of sodium p-chlorophenolate with m-dichlorobenzene in the presence of a copper catalyst and an aliphatic glycol dialkyl ether which is liquid under the reaction conditions, preferably adding potassium salt such as potassium chloride, preferably at 140-180 deg.C. The reaction is desirably conducted in an inert gas. The aliphatic glycol dialkyl ether is, e.g., diethylene glycol diethyl ether and the quantity is 1-5 times the equivalent amount of sodium p-chlorophenolate. |