NOVEL GENE TLRC IMPARTING TYROSINE RESISTANCE USED IN STREPTOMYCES FRAGIE

摘要

The tlrC gene is a novel tylosin resistanceconferring gene isolated from Streptomyces fradiae and used to construct a number of cloning vectors for use in Streptomyces. One such cloning vector, plasmid pSKC10, can be obtained in S. fradiae JS87 under the accession number NRRL 18072. S. fradiae JS87 is the preferred host when the tlrC gene is used to select tylosin-resistant Streptomyces transformants.