Multimeric polypeptides of HLA-G including alpha1-alpha3 monomers and pharmaceutical uses thereof

摘要

Multimeric polypeptides and pharmaceutical uses thereof; multimers comprising alpha3 and alpha1 peptides of an HLA-G antigen and methods of producing such multimers, pharmaceutical compositions comprising the same, as well as their uses for treating various diseases including organ/tissue rejection. Said multimers comprise at least two monomers, each of said monomers being selected in the group consisting of a peptide P2 of formula P1-X3 or X2-X3, wherein P1 is of formula X1-X2, wherein X1 represents a peptidic linker including a cysteine amino acid and X2 represents an alpha1 domain (or alpha1 peptide) of HLA-G and X3 represents an alpha3 domain of HLA-G.

主权项

1. A multimer, comprising:
at least two monomers each selected from the group consisting of a peptide P2 consisting of formula P1-X3 and a peptide P2 consisting of formula X2-X3, wherein P1 is a peptide of formula X1-X2, X1 represents a peptidic linker X1 comprising at least 10 and up to 100 amino acids, and the peptidic linker X1 comprising cysteine at or in position 4 or less from the N-terminal end thereof, X2 represents an alpha1 domain of HLA-G, and X3 represents an alpha3 domain of HLA-G.