| 发明名称 |
ALPHA-CELL RE-GENERATION COMBINED WITH CONVERSION TO BETA CELLS |
| 摘要 |
The present invention relates to methods of generating a population of beta cells from a population of alpha cells, by contacting said population of alpha cells with GABA or a GABA receptor agonist, in combination with a monoclonal glucagon neutralizing antibody or other alpha cell mass regulating compounds, for an improved diabetes therapy. |
| 申请公布号 |
WO2016102657(A1) |
申请公布日期 |
2016.06.30 |
| 申请号 |
WO2015EP81141 |
申请日期 |
2015.12.23 |
| 申请人 |
NOVO NORDISK A/S;INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE);CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE DE NICE SOPHIA ANTIPOLIS-GRAND CHÂTEAU |
发明人 |
HECKSHER-SØRENSEN, JACOB;COLLOMBAT, PATRICK |
| 分类号 |
A61K39/00;A61K31/197;A61K35/39;A61K45/06;A61P3/10;C12N5/071 |
主分类号 |
A61K39/00 |
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