发明名称 |
BENZOXAZINO OR BENZOTHIAZINORIFAMYCIN DERIVATIVE |
摘要 |
NEW MATERIAL:The compound of formula I (n is 1-5; X is O or S; R<1> and R<2> are H, 1-4C alkyl or 1-4C hydroxyalkyl) and its salt. USE:A medicine. An antibacterial agent. It is a solid having dark red color, soluble in a number of organic solvents, exhibiting strong antibacterial activity against Gram-positive bacteria and acid-fast bacteria and having low toxicity. It can be used as a production raw material for novel rifamycin derivative of formula II having strong antibacterial activity. It is administered at a rate of 10mg-10g of the active component daily for adult. PREPARATION:The compound of formula I can be produced by reacting a rifamycin derivative of formula III with an amine of formula IV in an organic solvent such as methanol in the presence of a reducing agent such as sodium cyanoborohydride at room temperature for 30min - about 1 month, thereby effecting reductive amination reaction. |
申请公布号 |
JPS6335578(A) |
申请公布日期 |
1988.02.16 |
申请号 |
JP19860181165 |
申请日期 |
1986.07.31 |
申请人 |
KANEGAFUCHI CHEM IND CO LTD |
发明人 |
YAMANE TAKEHIKO;KONDO HIDEO;HASHIZUME TAKUSHI;YAMASHITA KATSUJI;HOSOE KAZUNORI;WATANABE KIYOSHI |
分类号 |
C07D498/18;A61K31/535;A61K31/54;A61P31/04;C07D265/00;C07D273/00;C07D279/00;C07D307/00 |
主分类号 |
C07D498/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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