PRODUCTION OF HEPATISIS B VIRUS CORE ANTIGEN (HBCAG) IN YEAST

摘要

Hepatitis B virus core antigen (HBcAg) has been expressed in yeast at levels approaching 30% of the soluble yeast proteins. The expressed 22,000 dalton polypeptide aggregates into 28 nm particles which are morphologically and immunologically indistinguishable from native HBcAg particles. This protein is useful in in vitro diagnostic systems and in vaccines for treatment and prevention of hepatitis B virus-induced diseases and/or infections.