发明名称 |
PURIFICATION OF THE TWO IONIC FORMS OF SOMATOMEDIN C (INSULIN-LIKE GROWTH FACTOR 1) |
摘要 |
Two different ionic forms of somatomedin C (pI 6.7-7.0 and pI 8.3-8.6) can be isolated substantially free of each other by applying an aqueous solution of purified or partially purified somatomedin C containing both ionic forms at a pH of about 4.5 to 6.5 to a strong cation-exchange column, eluting the somatomedin C from the column by applying an aqueous salt gradient at an essentially constant pH and recovering the two ionic forms in different eluant fractions. |
申请公布号 |
AU7671087(A) |
申请公布日期 |
1988.02.11 |
申请号 |
AU19870076710 |
申请日期 |
1987.08.06 |
申请人 |
INTERNATIONAL MINERALS & CHEMICAL CORP., |
发明人 |
BRUCE D. BURLEIGH;DARLA S. MURPHY |
分类号 |
C12P21/00;A61K38/00;A61K38/22;A61P17/00;A61P43/00;C07K1/18;C07K14/00;C07K14/575;C07K14/65;C12P21/02 |
主分类号 |
C12P21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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