| 摘要 |
5-Phenoxy-2,2-dimethyl- 1-oxopentylaminobenzene derivs. of formula (I) are new (only 1 AB gp. is present; R1 is H, OH, 1-6C alkyl, 1-6 alkoxy, benzyloxy or CF3; R2 is H, OH, halogen, 1-6C alkyl or 1-6C alkoxy; A is (CH2)m or CR4:CR5; m is 1-3; R4 and R5 are H or 1-6C alkyl and are trans to each other; B is COOX; X is H, 1-6C alkyl, NH4 or a metal or organic amine cation; and k is 0 or 1. When k is 0, then R1 is not alkyl and when k is 1, then R1 the 4-position). (I) are antiarteriosclerotic agents, as they cause an elevation in the high density lipoprotein fraction of cholesterol and some cpds. reduce the low density lipoprotein fraction of cholesterol. Dose is 10-250 mg/kg daily. |
