| 摘要 |
<p>Thiazole derivatives represented by general formula (I) and salts thereof, wherein R?1 and R2¿ may be the same or different and each represents a C¿1? - C6 alkyl group, R?3¿ represents a hydrogen atom or a C¿1? - C6 alkyl group, or R?2 and R3¿ may be bound to each other to form -(CH¿2?)4-, R?4 and R5¿ may be the same or different and each represents a hydrogen atom, a C¿1? - C20 alkyl group, a phenyl group, a phenylthio group, a C1 - C6 alkylthio group, a C1 - C6 alkylthio-C1 - C6 alkyl group, a halogen atom, a nitro group, a C1 - C6 alkoxycarbonyl-C2 - C6 alkenyl group, a carboxy-C2 - C6 alkenyl group, a carbazoyl group, a carboxyl group, a carboxy-C1 - C6 alkyl group, a C1 - C6 alkoxycarbonyl-C1 - C6 alkyl group, a C1 - C6 alkoxycarbonyl group, a piperidinocarbonyl group, an N,N-di(C1 - C6 alkyl)aminocarbonyl group, an N-phenylaminocarbonyl group or a hydroxy-C1 - C6 alkyl group, and A represents an imino group, an oxygen atom, a sulfur atom, a sulfinyl group, a sulfonyl group or a C1- C6 alkylene group, provided that the case wherein R?3¿ represents a hydrogen atom, R4 represents a C¿1? - C6 alkyl group or a phenyl group, R?5¿ represents a hydrogen atom, and A represents an imino group is excluded. These compounds have a particularly excellent effect of inhibiting neoplasia of blood vessel, and are useful for treating malignant tumors, retinitis, psoriasis, etc.</p> |
