DNA SEQUENCES CODING FOR MODIFIED FACTOR VIII:C AND MODIFIED FACTOR VIII:C-LIKE POLYPEPTIDES AND PROCESSES FOR PRODUCING THESE POLYPEPTIDES IN HIGH YIELDS

摘要

DNA sequences coding on expression for modified factor VIII:C and modified factor VIII:C-like polypeptides and methods of making them in high yields in appropriate hosts transformed with those DNA sequences. DNA sequences containing internal deletions removing a major part of the sequence which codes on expression for the maturation polypeptide of factor VIII:C express modified factor VIII:C and modified factor VIII:C-like polypeptides 20 times more efficiently than DNA sequences coding for the factor VIII:C.