| 主权项 |
1. A therapeutic apparatus for treating a subject comprising:
a first heating unit adapted for heating a first region of the subject, a first control unit adapted for controlling the power directed into the first region by the first heating unit such that the power stays below a threshold value,
a particle heating unit adapted for heating magnetic nanoparticles within a second region of the subject using a time varying magnetic field, wherein the first region includes the second region, wherein the first heating unit is an ultrasonic heating unit, wherein the threshold value is selected such that the temperature increase in the first region due to the ultrasonic heating unit does not induce cell death, wherein the second region includes at least one hyperthermia zone induced by the temperature increase in the first region due to the ultrasonic heating unit, wherein the at least one hyperthermia zone has a concentration of magnetic nanoparticles sufficient to cause a temperature increase after the ultrasonic heating which induces cell death when heated by the particle heating unit, and wherein the ultrasonic heating unit is a high intensity focused ultrasound unit, wherein the particle heating unit modulates the magnetic field in the second zone such that it heats the magnetic nanoparticles using one of the following mechanisms: Brownian relaxation, Néel relaxation, or a combination of Brownian relaxation and Néel relaxation. |
