Methods, systems, and arrays for biomolecular analysis

摘要

Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.

主权项

1. An inverted pillar plate for assaying microarrays, comprising:
a clip comprising a body and a plurality of chip mounts, each chip mount comprising at least one chip holder extending from the body and configured to affix by extending around and holding therein at least one of a plurality of microarrays and to prevent the at least one microarray from being displaced from the chip mount when the chip mount is placed facing downwards into a well containing an assay solution; and a plate comprising a plurality of inverted plate pillars that extend from the plate, each inverted plate pillar configured to be coupled to one of the plurality of chip mounts, wherein each chip mount is configured to be affixed to at least one of the plurality of inverted plate pillars so that each chip mount is prevented from being displaced from the at least one inverted plate pillar when the plate is turned upside down.