| 摘要 |
NEW MATERIAL:C-304 Substances A and B having the following physical and chemical properties. Melting point: substance A, 181 deg.C and substance B, 196 deg.C. Molecular formula: substance A, C9H7NO3S and substance B, C18H17N3O6S2. Molecular weight: substance A, 209 and substance B, 435, etc. USE:An aldose reductase inhibitor suppressing extraordinary rise in sorbitol content in cell in diabetic. PREPARATION:A strain such as Actinosynnema sp. C-304 (FERM P-8836), etc., belonging to the genus Actinyosynnema is cultivated preferably under an aerobic condition at about 30 deg.C at pH 6-8 for 1-5 days. |
