COMPOSITION FOR PREVENTION AND TREATMENT OF COGNITIVE DISORDER COMPRISING EXTRACTS OF MULBERRY

摘要

The present invention relates to a pharmaceutical composition for preventing or treating cognitive dysfunction syndrome, comprising a mulberry extract as an active ingredient. According to the present invention, the pharmaceutical composition derived from natural plants does not have biological toxicity, and has effects in recovering a related signaling path, the expression of antioxidant enzyme, and GSH reduced by intracellular oxidative stress in nerve cells. The pharmaceutical composition has effects in being protected from the apoptosis, such as the inhibition of the expression of apoptosis-related protein or the like. Accordingly, the pharmaceutical composition can be applied to the prevention or the treatment of neurodegenerative diseases such as trauma, a stroke, Alzheimers disease, and the like generated by glutamate.