| 摘要 |
PROBLEM TO BE SOLVED: To provide an aerosolizable formulation comprising a drug, a carrier and pH affecting component.SOLUTION: The drug is dissolved in the formulation at a concentration above which it remains in solution at neutral pH. This increases the concentration of the drug in solution making it possible to administer larger amounts of drug with the same or a smaller volume of formulation. When the formulation is aerosolized to small particles and inhaled into human lungs in small volumes (e.g. 0.05 to 0.5 mL), the fluids in the lungs neutralize the formulation and the drug precipitates out of the solution. As a result, the drug is delivered at a controlled rate below the rate at which drug is administered from a formulation initially at a neutral pH. The drug is gallium nitrate, preferably a gallium salt. The pH effecting agent deviates formulation pH by 0.75 to 4.15 log units, particularly preferably by 1.0 to 2.01 log units or more away from 7.4.SELECTED DRAWING: None |
