发明名称 |
Method for inhibiting bone resorption |
摘要 |
The invention is directed to a method of inhibiting bone resorption. The method comprises administering to a human an amount of sclerostin inhibitor that reduces a bone resorption marker level for at least 2 weeks. The invention also provides a method of monitoring anti-sclerostin therapy comprising measuring one or more bone resorption marker levels, administering a sclerostin binding agent, then measuring the bone resorption marker levels. Also provided is a method of increasing bone mineral density; a method of ameliorating the effects of an osteoclast-related disorder; a method of treating a bone-related disorder by maintaining bone density; and a method of treating a bone-related disorder in a human suffering from or at risk of hypocalcemia or hypercalcemia, a human in which treatment with a parathyroid hormone or analog thereof is contraindicated, or a human in which treatment with a bisphosphonate is contraindicated. |
申请公布号 |
LT2556841(T) |
申请公布日期 |
2016.09.12 |
申请号 |
LT20120180292T |
申请日期 |
2008.09.17 |
申请人 |
Amgen, Inc |
发明人 |
Padhi, Ian, Desmond;Jang, Graham, Richard |
分类号 |
A61K39/395;A61P19/08;C07K16/18 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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