| 发明名称 |
STEREOSELECTIVE PROCESS FOR THE PREPARATION OF ANTHRACYCLINE DERIVATIVES |
| 摘要 |
A stereoselective process for the preparation of a 4 min -0-tetrahydropyranyl derivative of an anthracycline compound having a daunosamine residue by reacting an anthracycline compound of the formula <CHEM> wherein R represents a hydrogen atom, a halogen atom or a protected hydroxyl group, or an acid addition salt thereof, with 3,4-dihydro-2H-pyran in an inert solvent in the presence of a metal-containing Lewis acid, and isolating the desired stereoisomer by a usual method. |
| 申请公布号 |
DE3468219(D1) |
申请公布日期 |
1988.02.04 |
| 申请号 |
DE19843468219 |
申请日期 |
1984.07.03 |
| 申请人 |
MICROBIAL CHEMISTRY RESEARCH FOUNDATION |
发明人 |
UMEZAWA, HAMAO, PROF.;TAKEUCHI, TOMIO;TATSUTA, KUNIAKI;TAKAHASHI, YOSHIKAZU |
| 分类号 |
A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61P35/00;B01J27/125;B01J27/128;B01J27/135;C07B61/00;C07H15/252;(IPC1-7):C07H15/252 |
主分类号 |
A61K31/70 |
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