L-ASPARTYL-L-PHENYLALANINE METHYL ESTER HAVING IMPROVED SOLUBILITY

摘要

A process for producing dry alpha -L-aspartyl-L-phenylalanine methyl ester having an improved solubility from wet crystals of alpha -L-aspartyl-L-phenylalanine methyl ester having a water content of at least 20% by weight, which comprises drying the wet crystals at a temperature of higher than 50 DEG C to obtain moist crystals having a water content of less than 20 and more than l5% by weight, then drying the moist crystals at a temperature of not higher than 50 DEG C to obtain semi-dry crystals having a water content of less than 5% by weight, and further drying the semi-dry crystals at a temperature of higher than 50 DEG C to obtain dry crystals of alpha -L-aspartyl-L-phenylalanine methyl ester.