Synthesis of azetidinones.

摘要

A process for producing a compound having the formula wherein Pr is hydrogen or a hydroxy protecting group and Pr<1> is a carboxy protecting group, comprising reacting a compound of the formula wherein Pr is as previously defined, with a compound having the formula Pr<1>-OH, wherein Pr<1> is as previously defined and either mineral acid or a silver salt of an organic base, and reacting the product so produced with a compound having the formula: wherein L is a leaving group. Three reaction schemes are disclosed as well as novel intermediate compounds.