发明名称 |
Sustained release ibuprofen formulation. |
摘要 |
<p>The present invention provides a sustained release alpha -4-(2-methylpropyl)benzene acetic acid (Ibuprofen) formulation comprising sufficient granules to provide a predetermined dose or number of doses of Ibuprofen, each granule having a diameter between 0.5 and 2.0 mm and comprising: a) a core containing l00 parts of Ibuprofen and from l0 to 70 parts of a microcrystalline cellulose; and b) a coating covering substantially the whole surface of the core and comprising l00 parts of a water insoluble but water swellable acrylic polymer and 20 to 70 parts of a water-soluble hydroxylated cellulose derivative, the weight of the coating being from 5 to 20% of the weight of the core. i</p> |
申请公布号 |
EP0255404(A1) |
申请公布日期 |
1988.02.03 |
申请号 |
EP19870306837 |
申请日期 |
1987.07.31 |
申请人 |
APS RESEARCH LIMITED |
发明人 |
BARRY, BRIAN WILLIAM;YORK, PETER;MULLEY, BRYAN ARTHUR |
分类号 |
A61K9/16;A61K9/20;A61K9/22;A61K9/32;A61K9/36;A61K9/50;A61K31/19;A61P25/04;A61P29/00;(IPC1-7):A61K9/20 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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