摘要 |
<p>A method for the treatment and/or prophylaxis of hyperglycaemia in human or non-human mammals which comprises administering to the mammal in need of such treatment and/or prophylaxis an effective non-toxic amount of: a compound of formula (I): <CHEM> or a pharmaceutically acceptable acid addition salt thereof, wherein each of R<1> and R<2>, which may be the same or different, represents a hydrogen or halogen atom, or an alkyl or alkoxy group containing 1 to 4 carbon atoms, X represents an oxygen or sulphur atom, an imino group, an acylimino group containing 2 to 4 carbon atoms in the acyl group, or a methylene group, each of n and m, which may be the same or different, represents the number 1, 2 or 3, and p represents the number 2 or 3; with the proviso that when the moiety <CHEM> is present in formula (I), then either R<1> or R<2> must represent hydrogen; or a compound of formula (II): <CHEM> or a pharmaceutically acceptable acid addition salt thereof, wherein each of R<3> and R<4> may be either a hydrogen or halogen atom; or an alkyl or alkoxy group either of which groups may have from 1 to 4 carbon atoms; providing that either R<3> or R<4> must be hydrogen; R<5> and R<6> can be identical or different and either a hydrogen or an alkyl with 1 to 4 carbon atoms, and R<7>, R<8>, R<9>, and R<1><0> can be identical or different and either hydrogen or an alkyl with 1 to 4 carbon atoms, or in which R<7> and R<8> together represent an ethylene group with the further proviso that when R<7> and R<8> represent an ethylene group then at least one of R<5>, R<6>, R<9> and R<1><0> represents an alkyl group with 1 to 4 carbon atoms; and compositions for use in such method.</p> |