发明名称 |
4(3H)-Oxo-5,6,7,8,-Tetrahydropyrido-(2,3-d)Pyrimidine derivatives. |
摘要 |
<p>The invention pertains to derivatives of N-[4-(N-[2-amino-4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6- ylmethyl]a mino)benzoyl]-L-glutamic acid of the formula: <CHEM> wherein R<1> is hydrogen, methyl, ethyl, or R<5>CO-; R<2'> and R<3'> are hydrogen or a carboxylic acid protecting group; R<4'> is hydrogen or an amino protecting group; and R<5> is hydrogen or alkyl and the configuration about the carbon atom designated * is L, which derivatives are antineoplastic agents, to their preparation and use, and to intermediates useful in their preparation.</p> |
申请公布号 |
EP0255228(A1) |
申请公布日期 |
1988.02.03 |
申请号 |
EP19870305636 |
申请日期 |
1987.06.24 |
申请人 |
THE TRUSTEES OF PRINCETON UNIVERSITY |
发明人 |
TAYLOR, EDWARD C.;BEARDSLEY, GEORGE PETER;SHIH, CHUAN;HAMBY, JAMES M. |
分类号 |
A61K31/505;A61K31/519;A61P35/00;C07D471/04;(IPC1-7):C07D471/04;A61K31/435 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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