| 摘要 |
An element of DNA of about 1,500 base-pairs is disclosed, which is endowed with the typical properties of an IS insertion element, present in one or more copies, and on different sites in the chromosomal DNA of strains of C. diphtheriae. Molecule of recombinant DNA obtained from the splicing of a clonation vector with a DNA segment containing said insertion element or fragments thereof, and microorganism transformed with said molecule of recombinant DNA. The IS insertion element is useful for the preparation of strain-specific hybridization probes, which can be used for the characterization and the epidemiological study of strains of C. diphtheriae. |
