FORFARANDE FOR FRAMSTELLNING AV FOSFONSYRADERIVAT GENOM ODLING AV EN STAM HORANDE TILL STREPTOMYCES RUBELLOMURINUS, STREPTOMYCES RUBELLOMURINUS SUBSP. INDIGOFERUS ELLER STREPTOMYCES LAVENDULAE

摘要

New antibiotics, their derivatives and their process of preparation are described of formula: (I) wherein R is acetyl and A is trimethylene or 2-hydroxy-tri-methylene, and R is formyl and A is trimethylene or trans-1-propenylene; the antibiotics are produced by cultureing an antibiotic (I) producing strain belonging to the genus Streptomyces in an aqueous nutrient medium under aerobic conditions until substantial antibiotic activity is imparted to said medium; the antibiotic is then recovered from the medium; the now antibiotics have antimicrobial activity against various pathogenic microorganisms including those of the genera Bacillus, Sarcina, Escherichia and Salmonella.