GLYCOSYLAMINE UND DEREN N-ALKYLIDEN-DERIVATE

摘要

O-acyl-protected glycosylamines, in particular 2,3,4,6-tetra-O-pivaloyl- beta -D-galactopyranosylamine (1), their preparation and their use for the diastereoselective synthesis of alpha -aminoacids. With compounds such as (1), one can obtain by Strecker synthesis high yields and high diastereomer surplus. The direction of the asymmetric induction can be determined by the selection of the solvent. This type of synthesis is particularly effective when carried with Lewis acid catalysts. One obtains also high yields and high diastereoselectivity during Ugi four component synthesis facilitated by Lewis acids by using amines such as (1).