| 摘要 |
<p>NEW MATERIAL:A compound shown by formula I [R1 is H or CH3; group shown by formula II is single bond (in this case R2 is aryl, aralkyl, heteroaryl, etc.; X-A is case where X is O or NH and A is aryl or X is O or S and A is alkyl, aralkyl, alkenyl, etc.) or unsaturated double bond (in this case R2 is H, alkyl, alkenyl, alkynyl, etc.; X is S; A is alkyl, aralkyl, alkenyl, etc.)], its pharmaceutically acceptable ester, amide or salt. EXAMPLE:4-[1-Phenyl-2-(imidazol-1-yl)ethylthio]butyric acid methyl ester. USE:A remedy for circulatory diseases resulting from thromboxane A2. PREPARATION:A compound shown by formula III is reacted with a compound shown by formula IV (R2 and X-A are the above-mentioned groups when group shown by formula II is single bond; W is eliminable group; R3 is H or carboxyl- protecting group) and optionally the protecting group is removed to give a compound shown by formula V among compounds shown by formula I.</p> |
