BATA-LACTAMFORBINDELSE, FREMGANGSMAADE TIL FREMSTILLING DERAF, FARMACEUTISKE PRAEPARATER INDEHOLDENDE FORBINDELSEN SAMT MELLEMPRODUKTER TIL ANVENDELSE VED FREMSTILLINGEN DERAF

摘要

There are disclosed a beta -lactam compound represented by the formula (I): wherein R1 and R2 are independently a hydrogen atom or a lower alkyl group; M is a hydrogen atom, a protective group or an eliminatable group which is easily hydrolyzable in a human body; R' and R'' are independently a hydrogen atom or a protective group; A is a mercapto group substituted by a substituted or unsubstituted polycyclic nitrogen-containing heterocyclic ring or a group represented by the following formula (a): -OOCNR3R4 (a) where R3 and R4 are independently a hydrogen atom or a lower alkyl group, provided that R1 and R2 are both hydrogen atoms, both R3 and R4 being hydrogen atoms are excluded, or its pharmaceutically acceptable salt, and a method for preparing the same, medicinal composition for microbism therapy containing the same and intermediates for synthesis of the same.