| 摘要 |
Attenuated E. necatrix suitable for use in the production of a live vaccine is produced by passaging pathogenic E. necatrix in embryonated eggs for a sufficient number of passages i.e. from about 20 up to about 50 or more egg passages. The live egg-attenuated E. necatrix of the invention may be formulated in vaccines, e.g. feed or drinking water vaccines, for prevention and control of coccidiosis in poultry, usually with other strains of Eimeria (i.e. E. acervulina, E. brunetti, E. maxima, E. mivali, E. praecose and E. tenella) as live pathogenic strains thereof or preferably attenuated non-pathogenic lines thereof. In a preferred embodiment the egg-attenuated E. necatrix of the invention is formulated in a vaccine comprising attenuated, precocious E. acervulina. |
