| 摘要 |
The invention relates to cycloalkyl-substituted 4-pyridyl derivatives of formula (I) <CHEM> wherein R is C1-C4 alkyl; each of R1 and R2 is, independently, hydrogen or C1-C4 alkyl; n is an integer of 1 to 5; and either (a) A is >C=O and B is -O-, -NH- or -CH2-; or (b) A is -CH2- and B is -O-, -NH-, -CH2- or >C=O; or (c) A is -O- and B is >C=O or -CH2-; or (d) A is -NH- and B is >C=O or -CH2-, and their pharmaceutically acceptable salts. The compounds of the invention show aromatase inhibiting activity and can be useful, e.g., in treating hormone-dependent tumors and prostatic hyperplasia. |
