发明名称 |
Modified tissue plasminogenen activator. |
摘要 |
<p>Novel modified tissue plasminogen activators (t-PA) are described. The novel t-PA's are single-chained molecules being cleaved at one or more positions in the peptide sequence extending from Cys(409) to Cys(44l) and capable of being activated in the presence of plasmin. The novel products are formed by cleavage of tissues plasminogen activators and are useful in treatment of vascular disorders.</p> |
申请公布号 |
EP0253582(A1) |
申请公布日期 |
1988.01.20 |
申请号 |
EP19870306099 |
申请日期 |
1987.07.10 |
申请人 |
NOVO NORDISK A/S |
发明人 |
WALLEN, PER BRUNO;NORRMAN, BO ANDERS;NEXO, BJORN ANDERSEN |
分类号 |
C12N9/64;A61K38/00;A61K38/46;A61P7/02;C07K14/00;C12N9/72 |
主分类号 |
C12N9/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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