ANALOGIFREMGANGSMŸTE FOR FREMSTILLING AV NYE, TERAPEUTISK VIRKSOMME (3,2,0)-BICYCLOHEPTANOXIMETHERE OG DERES IKKE-TOKSISKE SALTER.

摘要

Compounds useful in treating cardiovascular disorders are the carboxylic acids depicted in formulas (1) and (2) (1) (2) as well as their pharmaceutically acceptable, non-toxic salts and esters, wherein: n is an integer from one to four; R1 is hydroxy; R2 is hydrogen; or R1 and R2 together are an oxo group; R3 is wherein A is -CH2-CH2-; trans-CH=CH-; -C 3BOND C-; and R4 is linear or branched alkyl of one to twelve carbons, cycloalkyl of three to eight carbons; phenyl optionally substituted with one or two identical substituents selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and halo; or optionally substituted phenylalkyl.