发明名称 |
SUBSTITUTED ISOQUINOLINE DERIVATIVES, METHOD FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS |
摘要 |
Substituted isoquinolines of the formula <IMAGE> I wherein R is lower alkoxy, n is the integer zero or 1, and A is <IMAGE> <IMAGE> <IMAGE> wherein R1 is phenyl, halophenyl, lower-alkylphenyl or lower-alkoxyphenyl, and pharmaceutically acceptable acid addition salts thereof, are described. The compounds of formula I are useful in the treatment of cerebral and cardiac ischemias. |
申请公布号 |
EP0126480(B1) |
申请公布日期 |
1988.01.20 |
申请号 |
EP19840105777 |
申请日期 |
1984.05.21 |
申请人 |
F. HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT |
发明人 |
BRUDERER, HANS, DR.;KIERSTEAD, RICHARD WIGHTMAN;MULLIN, JOHN G., JR.;NAKAMURA, KEIJI;O'BRIEN, JAY PHILIP;TATEISHI, MITSURU;TEITEL, SIDNEY |
分类号 |
C07D295/20;A61K31/47;A61K31/472;A61K31/495;A61P7/02;A61P9/00;A61P9/10;A61P25/02;C07C233/45;C07D217/18;C07D217/20;C07D217/26;C07D241/04;C07D241/08;C07D295/205;C07D295/22;C07D295/24;C07D401/06 |
主分类号 |
C07D295/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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