| 摘要 |
NEW MATERIAL:A compound shown by formula I [X is amino-protecting group of -COR<1>(R<1> is t-butyloxy, phenyl, etc.) or H; Y is H, methyl, ethyl, acetyl, etc.; R<2> and R<3> are H or carboxyl-protecting group; Z is H, OH, alkoxy, etc.; the second and the fifth positions are in (S) and (R) configuration, respectively]. EXAMPLE:1-Benzyloxycarbonyl-2(S)-methoxycarbonyl-5-methoxypyrrolidine. USE:An intermediate for synthesizing carbapenem of beta-lactam antibiotics by a simple production process at low cost. PREPARATION:A pyrrolidine derivative shown by formula II is reacted with a carbon nucleophilic reagent (e.g. ketene silyl acetal, acetoacetic ester or malonic ester) in the presence of Lewis acid to give a compound shown by formula I. |
